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Therefore, ACTH pulsatile secretion plays a primary role in the gene regulation of critical enzymes and receptors involved in cortisol synthesis and secretion by the adrenal gland

Lamers, Y., Williamson, J., Gilbert, L

& Despa, F

Therefore, it is imperative that dysregulated metabolites of lipids and amino acids, other than high glucose might be other major metabolic factors that might implicate in the pathophysiology of early retinal damage in DR

This microbial stability could serve a protective function, allowing for compositional shifts (as seen in beta diversity) without compromising overall diversity

JAMA 2002;288:6989