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It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity

Applying a one-size-fits-all approach increases the risk of precipitation, aggregation, oxidation, and reduced experimental reproducibility

Nawarathne et al

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Haslbeck KM, Neundorfer B, Schlotzer-Schrehardtt U, Bierhaus A, Schleicher E, Pauli E, Haslbeck M, Hecht M, Nawroth P, Heuss D: Activation of the RAGE pathway: a general mechanism in the pathogenesis of polyneuropathies
