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doi: 10.1186/2046-4053-1-33 186 Del DottoPBonuccelliU

Human Data: While animal studies (mostly in rats) are overwhelmingly positive, large-scale, peer-reviewed human clinical trials are still limited

Vitamin E was found to significantly reduce cognitive performance in patients with mild to moderate AD in a multicentre, randomised, double-blind, placebo-controlled trial of AD from 2007 to 2012

However, memory is vulnerable across the adult lifespan

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We identified 678 upregulated and 841 downregulated genes associated with DRM1/2-dependent CHH hypermethylation during LEC2-induced SE formation (Fig