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Marino and Gladyshev suggested that these extreme patterns are likely indicative of strong selective pressure to keep Cys or Trp residues in functionally important locations and to remove them from others [9]

[DOI] [PMC free article] [PubMed] [Google Scholar] 64.Janz R

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The PI3K was demonstrated to be involved in MOR desensitization on the inhibition of voltage-gated calcium channels induced by chronic morphine treatment (Konig et al., 2010)