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Both the presence of LA and increased level of ACA are associated with a 3- to 10-fold increased risk of venous thrombosis.41 An elevated level of the amino acid, homocysteine is now generally accepted to be a risk factor for systemic vascular disease.42 Homocysteine appears to have a deleterious effect on vascular endothelium and may induce increased platelet aggregation and thrombosis

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Cai A, Zheng D, Qiu R, Mai W, Zhou Y

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Z.LuQ.DeitchE

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These latter transformations could be the molecular basis for eliminating foreign substances from the body

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In addition, painful diabetic neuropathy significantly reduces the expression of IGF-1 in spinal cord

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