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Tsou AY, Bulova P, Capone G, et al

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24,25 Leptin responsive neurons in the ARC include those containing the agouti-related peptide (AgRP) and orexigenic peptides neuropeptide Y (NPY), and those containing the anorexigenic peptides -melanocyte-stimulating hormone (-MSH) and cocaine and amphetamine-regulated transcript (CART)

Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice