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This patient's structural joint deformities and chronic stiffness without burning neuropathic pain or digital ischemia make a myeloproliferative neoplasm unlikely

Lower melanin levels can lead to a lighter and more even skin complexion

Lewy bodies and basal ganglia neuronal loss (about 70% of dopaminergic neurons in the substantia nigra pars compacta (SNpc) are the primary pathogenic features of PD

After removing the supernatant, the resulting pellet was resuspended in 200 l of B-PER reagent (supplemented with 1 mM DTT and 1 mM PMSF)

10.1093/genetics/163.1.335 76 De VitaS.FinamoreC.ChiniM

NAC is a substrate precursor of the xc- system [197, 203]