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LR3 binds IGF1R with affinity comparable to native IGF-1, with reported Kd values in the sub-nanomolar to low nanomolar range across multiple published cell line studies

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Network biology implemented computational models to interpret gene regulatory networks (GRNs) (289), protein-protein interaction (PPI) networks (290) and signaling cascades (291), characterizing the key modules, hubs, and bottlenecks linked with cancer phenotypes

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Journal of Cell Biology 1994, 125 (4): 929943