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Because A is an intermediate in the steroidogenic pathway, overexpressed TSPO would presumably compensate for the decrease in 22 R -hydroxycholesterol

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Nevertheless, metformin remains the typical first-line choice because of its well-established safety profile, efficacy, low cost, and wide accessibility (Wexler 2021b)

Because physical exercise increases demand on a weakened heart, measures of exercise tolerance are frequently used to monitor the severity of heart failure

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