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doi: 10.1016/j.conb.2017.05.018

Briefly, stabilization of HIF-1 as the prime mediator of the hypoxia response pathway is effectively exerted by prolyl hydroxylase domain (PHD) inhibitors (e.g., daprodustat, dimethyloxalylglycine or DMOG , roxadustat), HIF-1 inducers (e.g., albendazole, agmatine), modifiers of hemoglobin-oxygen affinity (e.g., HypoxyStat 150 ), and, less specific in its target, iron chelators (deferoxamine or DFO , deferiprone)
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Singcha, P., Khaksar, G., Sirijan, M
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The results of the excretion experiment showed that the main excretory pathways of BPC157 involve the liver and kidney, which was also consistent with the excretion characteristics of peptide drugs (Czock et al., 2012
