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Most of the cases of ALS are sporadic (sALS) with no genetic linkage, while around 10% are associated with familial forms (fALS), presenting mutations in over 20 genes

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A deficiency can also result from not getting enough B12 in what you eat due to various food restrictions

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Multidrug Resistance Proteins (MRPs): Structure, Function and the Overcoming of Cancer Multidrug Resistance. Drug Resistance Updates 54: 100743
