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Approximately 15% of Arg is metabolized in the liver and 60% in the gastrointestinal tract, and increased NO production through oral ingestion of Arg may be impaired [116]

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Over time, the metabolic consequences of insulin deficiency such as glucotoxicity (and potentially other phenomena such as lipotoxicity) cause further beta cell injury and dysfunction, leading to a vicious cycle that promotes yet more dysfunction and loss of beta cells (Figure 1)

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Set the pressure cooker to 120 minutes