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This gradual realization of the beneficial roles of protein oxidation may be attributed to accumulating evidence that ROS and RNS are indispensible for cell survival [18-22] and regeneration [23], and in many cases, they are required for recovery of cellular functions by creating positive stress conditions whereby cell survival mechanisms are reprogrammed to extend life span [24-27] or to withstand severe, or lethal challenges [28-31]

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doi: 10.1038/nature14136

Peptides labeled with CHCE displayed a greater signal intensity than the unlabeled peptides, despite the former being present in lower abundance