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Beyond vertebrates, GDAP1-related sequences with conserved domains and predicted structural homology have been observed in invertebrates

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Mechanistically, lactate accumulation inhibited glucose uptake and glycolysis leading to depletion of cellular ATP levels

Additionally, heme degradation and NCOA4-mediated ferritin autophagy can degrade ferritin, releasing iron into the labile iron pool (LIP) [64, 65], subsequently sensitizing cells to iron-induced atrophy via the Fenton response