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It was found that treatment with MPS/D-SEL significantly inhibited activation of neutrophils and macrophages, reduced the number of neutrophils, and promoted the polarization of M2-type macrophages in a mouse model of LPS-induced ALI

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[PMC free article: PMC2692902] [PubMed: 17991651] 387

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However, this association was limited to copper intake from food sources [58]

When several approximately equally active compounds are available, a drug that comes closer to these physicochemical and pharmacological (PK-PD) properties should be preferred