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Side effects are rare but possibly mild gastrointestinal upsets, loose stools or greenish urine (this is not harmful)

Some research suggests that very high caffeine intake, particularly during a creatine loading phase, may slightly blunt its benefits , but findings are mixed and not definitive

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Based on the relationship between CVD and hydrostatic pressure and osmotic pressure, some researchers have speculated that the increase in TMAO in CVD is a compensatory response

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