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These findings are consistent with those from a different study (Wancket et al., 2012), in which rats fed a diet rich in cocoa displayed raised basal levels of the MAPK phosphatases MKP-1 and MKP-3, preventing the cerebral peripheral flogosis caused by MAPK

Possible side effects are typically mild and temporary, including injection site reactions, occasional headaches, nausea, or lightheadedness, and a metallic taste in the mouth

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Modulating the CCS-SOD1 interaction could be a potential therapeutic target for ALS [77, 78]

When autoimmune responses to CII and oxPTM-CII were analyzed according to HLA-DRB1 subtypes, we found that ROS-CII but not native CII autoimmunity was restricted to the HLA Shared Epitope (SE) containing DRB1*04 alleles (112), known to confer the greatest risk for developing RA (OR 3-13) (113)