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T2DM and hyperglycemia are also associated with oxidative stress from the overproduction of reactive oxygen species (ROS) and decreased efficiency of scavengers systems ( Furthermore, our lab has previously shown that individuals with T2DM have lowered levels of GSH due to decreased levels of both GCL and GSS protein compared to healthy subjects ( M

Location of an inhibitory phosphosite at S251 in proximity to R-domain phosphosites The Lasso motif region adjacent to the R-domain also contains a conserved phosphorylation site that negatively regulates transport, S251 (T249 in the Ycf1 homolog MRP1) 16,17

DsbA belongs to the family of disulfide bond forming (Dsb) proteins in bacteria

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