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G6PDH exists as either an inactive monomer or an active dimer

For clarity, this review is focused only on the heterodimeric GCL

Thanks to dr Nikita sonavane

Reduced glutathione operates as the active, functional antioxidant form, making it particularly effective in neutralizing free radicals and supporting essential cellular processes advantages not matched by other variants such as oxidized glutathione

Key mechanisms, including genetic mutations, gene amplification, chromosomal rearrangements, and efflux transporters, contribute to the parasites ability to evade existing therapies

The half-life sits around 5 days, which is why weekly dosing works