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In summary, the accumulation of TMAO will not only increase oxidative stress and endothelial cell damage and permeability but also lead to an increase endothelial-derived NOS expression ( Vascular Calcification: TMAO Activates the NLRP3 Inflammasome and NF-B Signaling Pathway in Vascular Smooth Muscle Cells (VSMCs) Vascular calcification (VC) is a phenomenon of disseminated deposition of mineral content within the medial layer of arteries

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Expression of CXCL12 on hepatocytes may aid in the homing of UM cells to the liver microenvironment

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BRAF inhibitors are commonly used for melanoma patients whose tumors have BRAF mutations

Acknowledgements This paper is separate from that of Ph.D