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Neuromuscular diseases Amyotrophic lateral sclerosis (ALS) ALS is a degenerative disease caused by gain of function mutations associated with a dominant SOD1 phenotype, a gene encoding the cytosolic antioxidant enzyme Cu, Zn-superoxide dismutase
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Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism
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