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The original genetic-validation study used antisense oligonucleotide-mediated knockdown of NNMT in adipose tissue of mice on a high-fat diet, with whole-body and adipose-tissue metabolic endpoints measured against scrambled-oligonucleotide controls [2]

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Angiogenic peptides, such as vascular endothelial growth factor (VEGF) and FGF, stimulate endothelial cells to proliferate, migrate, and form capillary structures within the wound site