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This limits their ability to penetrate the skin, which will affect tyrosinase inhibition and skin delivery (Mortazavi and Moghimi, 2022)

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This paradoxical role stems from the hijacking of oxidative stress defense mechanisms by the tumor microenvironment, which transforms GPx4 from a protector to an accomplice in malignant progression

When high doses of vitamin B 12 are given orally, only a small percentage can be absorbed, which may explain the low toxicity (4)