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Konings, C

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Shah AM, Malhotra A, Kothari S, Baddoura W, Depasquale J, Spira R

Results A phenotypic screen identifies electrophilic compounds with senolytic activity To identify vulnerabilities of senescent cells, we took advantage of a library of electrophilic compounds (Methods) to conduct a senolytic screen (Fig

Evaluation of antioxidant and wound healing effects of alcoholic and aqueous extract of Ocimum sanctum Linn in rats

For either compound to move from no toxicity demonstrated to safety established for a defined use, the following would ordinarily be required and none of it is presently complete in the public record for these substances as sold: GLP-compliant repeated-dose toxicity of adequate duration typically up to chronic (6- to 12-month) studies in a rodent and a non-rodent species, with full clinical pathology and histopathology, to detect cumulative organ effects