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While embryonic NPCs primarily rely on glycolysis to meet their energy requirements, a metabolic shift toward oxidative phosphorylation (OXPHOS) from stem cells and neural progenitors to mature neurons are critical for proper human neurogenesis and involve specific metabolic regulators, including hexokinase II, lactate dehydrogenase and pyruvate kinase (Wang et al., 2016

To investigate, Huiying Li, a molecular pharmacologist at the University of California-Los Angeles, and her team decided to focus on high levels of B12 as a possible culprit, based on research from the past six decades thats linked it to higher instances of the condition

Personalized techniques that take into account genetic predisposition (e.g., APOE4) and metabolic state may further increase the efficacy of plant-based intervention (Bolengo, 2023

Hu C (2025) Prevention of cardiovascular disease for healthy aging and longevity: a new scoring system and related mechanisms-hallmarks-biomarkers. Ageing Res Rev 107:102727

The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4(+) T cells by preventing ferroptosis

Zheng Z, et al