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During prolonged exercise or heavy sweating, replacing electrolytes may also be beneficial

Whilst caloric restriction is therapeutically appropriate, inadequate attention to dietary quality and micronutrient density can result in nutritional deficiencies , including B12, folate, iron, and other essential nutrients

The appropriate dose is dictated entirely by the design of the experiment

However, it can also be given slowly intravenously or subcutaneously (injected into a vein or under the skin)

B12 is usually considered safe, but when combined with certain medications or other vitamins, things get complicated