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However, recent reports indicate that inhibiting the aggregation of pathogenic proteins may not result in clinical effects similar to those observed in preclinical studies [208]

Moreover, neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) promote dopaminergic neuron survival, synaptogenesis, and repair in PD

Uspenski Iu, P., et al., [Device laboratory and postmortem parallels in alcoholic hepatitis during combined therapy using thioctic (alpha-lipoic) acid]

Pak, T., Yoo, S., Miranda-Angulo, A

The body uses these proteins or peptides as signaling molecules for cell-to-cell communication allowing the body to turn on certain cell functions to trigger specific positive effects

doi: 10.1016/j.metabol.2017.10.001