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The main drawback of carboplatin is its myelo suppressive effect which causes the blood cell and platelet output of bone marrow in the body to decrease quite dramatically, sometimes as low as 10% of its usual production levels (Canetta, Rozencweig et al., 1985)

A final refinement of all models was performed against half-maps using Servalcat 103 , and the resulting statistics are reported in Supplementary Table 1

Environmental changes such as alteration of the colonic microbiome were also reported

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