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While peripheral ghrelin fails to reach these sites, intracerebroventricular ghrelin administration induces c- fos expression in many of these regions and promotes feeding, confirming that ghrelin acts centrally to convey orexigenic signals (Nakazato et al., 2001

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These pathological processes exacerbate A deposition and tau-mediated neurodegeneration, ultimately leading to neuronal death or functional deficits

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