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doi: 10.1016/j.cub.2016.06.066 328 ThomasA.BaillieG

Ubiquitination plays a multifaceted role within the circadian system, not only regulating the core clock loop but also mediating its downstream physiological outputs

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AKR1B1 together with GS-DHN is believed to stimulate the phospholipase C/protein kinase C (PLC-PKC) pathway and consequently activate NF-B

However, the inherent challenges of traditional animal-derived EVssuch as heterogeneity, scalability issues, and ethical concernshave driven researchers to explore more sustainable and safer alternativesPlant-derived extracellular vesicles (PDEVs) (Lian et al., 2022

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