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It has attracted growing interest in laboratory settings due to its interaction with pathways associated with nicotinamide N-methyltransferase (NNMT) activity and metabolic signalling mechanisms

This hypothesis is strengthened by studies where the experimental administration of anti-angiogenic agents in mice from different obesity models resulted in significant weight reduction and adipose tissue loss (222)

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Early and smaller studies suggested effects on fat metabolism and body fat distribution, but larger obesity trials did not show a robust, clinically meaningful weight loss outcome on their own