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Taken by mouth, only a relatively small fraction of L-carnitine actually makes it into your bloodstream studies put oral bioavailability at roughly 1418%, and it drops further at higher doses

I think these data show us why some patients do want to stay on opioids because it may be helping to boost their reward system deficits, at least a little bit. If you are wondering whether the pain levels, psychological measures or other clinical symptoms were different between the two patient groups, the answer is NO