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This convergent biochemical step crucially underlies the subsequent biological activity of Se and argues for inclusion of hydrogen selenide as the fourth endogenous gasotransmitter alongside nitric oxide, carbon monoxide and hydrogen sulfide.Endogenously generated hydrogen selenide is incorporated into numerous selenoprotein oxidoreductase enzymes, essential for maintaining redox-status homeostasis in health and disease

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Focusing on findings in rodents, Ron and Barak review the intracellular signalling cascades that underlie this transition and the molecular mechanisms that act against it.

Chemotherapy induced peripheral neuropathy (CIPN) is a major challenge, with increasing impact as oncological treatments, using potentially neurotoxic chemotherapy, improve cancer cure and survival