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The full (liposome-encapsulated) peak plasma levels of ribavirin in the 0% PEG liposomes (DPPC-based) after a single intravenous injection of 50 mg/kg in rats were found to be stable for several hours (half-life was estimated to be about 19 hours) at around 3 millimolar and free fraction in plasma was then around 4 micromolar
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The results demonstrated that BSPD-OH exhibited superior ionization efficiency in comparison to the other two AIE matrices, due to its greater number of phenolic hydroxyl groups
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43,44 GLP-1R is present in the CNS, and its absence might contribute to alterations in behavior, mood, or cognitive function
