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ROS can trigger OS, which negatively impacts sperm motility, morphology, and DNA integrity, resulting in reduced fertility [17]

Chronic kidney disease and obesity bias surrogate estimates of insulin sensitivity compared with the hyperinsulinemic euglycemic clamp

[18]J.S

Overall, these limitations might encourage the search of different approaches, which might combine a more favorable compliance and safety, with acceptable efficacy and with more affordable treatment regimens, and might be therefore particularly suited in a minority of patients experiencing one or more hindrances to PDE5i treatment

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