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L.RmuU.UrbanN.SchaeferM.et al (2018)

References 1 American Psychiatric AssociationDSM-5 Task Force

This late phase involves enhanced glutathione recycling via GR, pronounced activation of GSTs, and selective deployment of thiolredox regulators (TRXs, GRXs, and PRXs), rather than a global increase in antioxidant capacity (highlighted in Figure 6 )

Although not yet proven, these effects suggest that it is possible to activate PI3K/Akt/GSK3B/Fyn dependent signaling pathways through cardiac MT overexpression to prevent chronic IH-induced cardiomyopathy and downregulation of Nrf2

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doi: 10.1038/ng1658