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Its origin story is fascinating

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Fan X, Wang D, Chen X, Wang R

In contrast to the transport processes, where metabolite transport against a gradient proceeds by secondary active transport, the uptake of glutathione conjugates into the vacuole proceeds by an ATP-driven primary active transport (Fig
This suggests that knockdown of the YTHDC1 gene did not result in the upregulation of both GPX4 and FSP1 mRNA expression in A549 and H1299 cells

Shapiro, G