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MET activation is thus involved in brain plasticity, as suggested by the fact that HGF administration on hippocampal slices enhances the phosphorylation of the glutamatergic NMDA receptor subunit GluN1, augments the NMDA-mediated currents, and increases the amplitude of long-term potentiation (LTP) induced by elevated neuronal activity (Kato et al., 2012)

TRIUMPH-4: knee osteoarthritis plus obesity, the trial reported in December 2025

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doi: 10.1210/clinem/dgaa370 62

Gradual Improvements: Other benefits, including improved cognitive function and reduced inflammation, may take days or weeks to develop with consistent use