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The predisposition of different variants enhancing the susceptibility of oxidizing denatured Hb (Heinz bodies) to metabolites other than bilirubin is an area that needs to be explored to gain new insights on the heterogeneity of this disease phenotype

It is commonly investigated in preclinical research models relating to peptide signalling pathways, cellular communication mechanisms, and copper-associated biological processes

Animal experiments Experiments were performed on brain tissue samples from a previously published brain bank 35,39,44,45

PMID 14767299

Committee for Medicinal Products for Human Use (19 February 2021)

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes