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Others have shown that RNA i knockdown of the E01A2.1 gene in wild-type worms had no effect on lifespan under 1.5 mM paraquat challenge, whereas it decreased the lifespan of the long-lived daf-2 ( e1370 ) mutant [79]

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Many cancer cells also express mutated versions of normal proteins associated with growth, proliferation, and differentiation, which allows them to rapidly multiply and metastasize

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