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However, in the presence of oxidative or nitrosative stress, GST can form homodimers that alter the reduced states of cysteine residues in its structure, resulting in JNK dissociation from the GSTJNK heterocomplex and causing subsequent activation of the c-Jun protein

Naunyn-Schmiedeberg's Arch Pharmacol 397 , 81658188 (2024)

[DOI] [PubMed] [Google Scholar] Zeevalk GD, Bernard LP, Sinha C, Ehrhart J, Nicklas WJ

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Oxidative stress occurs when there's an imbalance between free radicals (unstable molecules that damage cells) and antioxidants (the molecules that neutralize them)

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