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Furthermore, since post-inflammatory hyperpigmentation can occur in patients with lichen sclerosus, and the latter disease is a risk factor for squamous cell carcinoma or melanoma [27, 28, 31], skin biopsies are often required in these patients to accurately diagnose the nature of the hyperpigmentation

Overall peace of mind (optimism, happiness, positivity, as well as loss of anger, envy, stress, anxiety, depression, etc.) is also attributable to reduced systemic inflammation, and this can be achieved through music (mainly positive feeling music, classical music and other moderate relaxing types, dancing, singing, painting, reading books), and generally, it has been shown that art and psychotherapies (including Pilates, yoga, etc.) help in mental health and chronic systemic inflammation decrease, and, possibly faith/religion [1140,1141,1142,1143,1144]

Al Rajabi A 1 , Castro GS, da Silva RP, Nelson RC, Thiesen A, Vannucchi H, Vine DF, Proctor SD, Field CJ, Curtis JM, Jacobs RL

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