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doi: 10.1101/gad.10.11.1382

Nat Rev Drug Discov 6(9):721733 Filip M, Bader M (2009) Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system

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Interestingly, here, though macroscopic p K a values were often predicted with reasonable accuracy, there was dramatically more disagreement among participants as to which microscopic transitions produced these values (with methods often disagreeing even as to the sign of the free energy change associated with certain transitions), indicating far more work needs to be done on p K a prediction methods

Seong AH, Lii YI, Lee J, Choi S, Kim IA, Suk J, et al

This randomized controlled study showed that a whole food, multi-ingredient nutritional intervention was well tolerated for 4 weeks with good palatability