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Similar to scrapie, -synuclein pathology spreads in the peripheral and enteric nervous systems, then to CNS, whereas Alzheimers tau pathology propagates within the CNS only, beginning in the brainstem then involving cortical areas in a characteristic pattern ( If MS were also a degenerative proteopathy, such trans-callosal prion-like spread could readily explain the precursory mirror lesions described above

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