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MK-677 has been studied in trials lasting 1224 months with generally good tolerance

Mller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, et al

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Chemotherapy : Causes mucositis, nausea, anorexia, malabsorption major driver of cancer cachexia

doi: 10.3390/ijms22137080