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P., Hare, D

However, when cells are exposed to oxidative stress, the nuclear accumulation and constitutive activation of Nrf2 will increase, which will promote cancer progression and is also an important cause of tumor drug resistance [85, 86]

The best compound was the pomalidomide-based PROTAC 23 , which was able to degrade targets with nanomolar potency (DC 50 value of 102 nM) and inhibit cell proliferation (IC 50 value of 2.2 M) of HCT116 cancer cells

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& Diano, S

Within host cells and the tracheal-respiratory interface, oxygen availability decreases to about 5%, reflecting microaerophilic conditions