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Handal KA, Schauben JL, Salamone FR

Upon reaching a confluent monolayer, a 200 L pipette tip was utilized to create a scratch

While this reflects a common approach in nutritional strategies, it prevents us from attributing the observed effects to a single supplement or ingredient

Such an effect was only observed when cells expressed pyridoxal kinase (PDXK), the enzyme that generates the bioactive form of vitamin B6 (pyridoxal-5-phosphate)

Additionally, ischemia triggers excessive glutamate release, leading to overactivation of NMDA receptors, which in turn causes excitotoxicity, oxidative stress, and neuroinflammation

JJ: Writing review & editing, Investigation