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Augustine De Civitate Dei VII 13, referencing also Quintus Valerius Soranus

Regarding the diagnostic imaging studies, X-ray, CT, and MRI were used in 2 (9.1%), 21 (95.5%), and 10 (45.5%) cases, respectively

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With these results in hand we became convinced that a clinically useful small molecule analog could be designed that possessed the important characteristics of metabolic stability, extended half-live, BBB penetrability and the capability to enhance cognitive functioning