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Insufficiently suppressed hepcidin given the degree of iron deficiency in PV patients strongly suggests that disordered iron metabolism is an important component of the pathobiology of PV

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Ferroptosis is associated with multiple psychiatric disorders, including major depressive disorder, stress-induced anxiety, post-traumatic stress disorder, autism spectrum disorder, and alcohol use disorder

Future research directions are also discussed to advance our understanding and treatment of free radical-associated diseases.

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