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Similarly, polymorphisms in GSTM1, the gene encoding the enzyme Glutathione S-Transferase Mu 1, have been associated with a lower incidence of cisplatin-induced neuropathy (Khrunin et al., 2010), while polymorphism of the CYP450 3A enzyme system can necessitate vincristine dose adjustments to prevent neurotoxicity (Mora et al., 2016)

As the NF-B expression is majorly dependent on the progressive expression of the TNF-, so the nuclear extracts were examined for NF-B pathway activation, and it was found that creatine significantly reduces the expression of the NF-B signaling pathway and alters anti-inflammatory responses [27]

In The American Journal of the Medical Sciences , edited by Isaac Hays, pp